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The acute form for human life is extremely dangerous because it causes a stroke or hemorrhage in the brain, which often leads to premature death. These conditions include the wear and tear associated with aging, high blood pressure, abnormal aging of blood vessels (atherosclerosis), diabetes, and brain hemorrhage. When this hardening occurs, the blood vessel experiences a narrowing that can make it more difficult for the blood to flow. Peripheral vascular disease (PVD) is a circulation disorder that causes narrowing of blood vessels to parts of the body other than the brain and heart. In children, any cause of occlusion or narrowing of blood vessels that supply the brain might present with symptoms similar to moyamoya. This narrowing of the blood vessels causes decreased blood flow to the area of the brain that the affected vessels supply. Similar to carotid stenosis in the neck, it is caused by a buildup of plaque in the inner wall of the blood vessels. The narrowing of the vessels of the brain in adults and children proceeds differently: it can happen suddenly, but it can be chronic. These trigger chemicals, such as serotonin, to narrow blood vessels. Moyamoya disease was first noted in Japan in 1957 and it is seen mainly in Japan and other countries in Asia. One aspect of migraine pain theory explains that migraine pain happens due to waves of activity by groups of excitable brain cells. Conditions that narrow or inflict long-term damage on your brain blood vessels also can lead to vascular dementia. Moyamoya disease (MMD) is a rare, progressive cerebrovascular disease that causes stenosis or a blockage to one or both of the primary blood vessels (internal carotid arteries) that supply the brain as they enter the skull. A decrease in blood flow to the brain can cause a severe headache, and often is accompanied by weakness, numbness, or changes in vision or sensation. Serotonin is a chemical necessary for communication between nerve cells. Stenosis, in general, refers to any condition in which a blood vessel -- such as an artery -- or other tubular organ becomes abnormally narrow. It can cause narrowing of blood vessels throughout the body. ; Causes of peripheral vascular disease include peripheral artery disease due to atherosclerosis, blood clots, diabetes, inflammation of the arteries, infection, injury, and structural defects of the blood vessels. Intracranial stenosis is a narrowing of the arteries inside the brain. Causes and Risk Factors. Causes include: narrowing of blood vessels; ... High blood pressure, narrowed arteries, or a head injury can be the cause. In many cases, small vessel disease in the brain is a consequence of atherosclerosis and occurs in a similar fashion to narrowing of larger blood vessels found elsewhere in the body. This is when fatty material builds up and hardens on an artery wall. TIAs may be caused by a variety of factors, including: Narrowing of the arteries, usually caused by atherosclerosis. narrowing of the small blood vessels deep inside the brain, known as subcortical vascular dementia or small vessel disease a stroke (where the blood supply to part of the brain is suddenly cut off, usually because of a blood clot ), called post-stroke dementia or single-infarct dementia This is what is referred to as vascular stenosis, and it affects the blood vessels leading to the brain, heart, and legs most often. Causes. Quick decreases in blood flow can come from blood vessels rupturing, a stroke, a head injury, or a structural weakening of blood vessel walls as can occur with an aneurysm. This material can break off and get lodged in smaller blood vessels in the brain. Narrowed or chronically damaged brain blood vessels.

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